⏱️ Time-critical: start within 72 hours

PEP Online —
Act Fast After HIV Exposure

Condom broke, or unprotected sex with a partner whose HIV status you don't know? PEP can prevent HIV, but only if started within 72 hours, and the sooner the better. VDOC doctors consult late at night, early in the morning, on Sundays and on public holidays.

Can't get a slot soon? Don't wait. Go to a clinic or emergency unit now.

⏱️ 72-Hour Window
🌙 Late Nights, Sundays & Holidays
🔒 Confidential
🩺 HPCSA-Registered GPs

If you have been sexually assaulted

⚠️ Please go in person to your nearest Thuthuzela Care Centre, hospital or police station as soon as you can. They provide PEP, emergency contraception, STI treatment, forensic examination and counselling free of charge. Call the GBV Command Centre on 0800 428 428 (24 hours), or 10111 in an emergency.

What is PEP, and do I need it?

PEP (post-exposure prophylaxis) is a 28-day course of HIV medicine taken after a possible exposure, to stop the virus from establishing an infection. It must be started within 72 hours, and the earlier it is started, the better it works.

You may need PEP after:

  • Vaginal or anal sex without a condom, or a condom that broke or slipped, with a partner who has HIV or whose status you don't know
  • Sharing needles or injecting equipment
  • A needlestick or sharps injury

Not every exposure needs PEP. The doctor will assess the risk with you, including your partner's HIV status and whether they are on treatment, and recommend what's right.

Why after-hours access matters

Exposures often happen at night and over weekends, when GP practices are closed. VDOC doctors consult early, late, on Sundays and on public holidays, so you don't lose hours of the 72-hour window waiting for Monday.

Getting PEP through VDOC

1

Book the earliest slot

Book online or on WhatsApp and choose the soonest available doctor. Note the time of the exposure.

2

Risk assessment

The doctor asks about the exposure, your health and any medication, confidentially and without judgement.

3

Prescription & testing

If PEP is appropriate, you get a prescription plus advice on baseline and follow-up HIV testing.

💡 Also consider: emergency contraception (most effective as soon as possible after sex) and STI testing. Ask the doctor about both during your consult. If you are at ongoing risk of HIV, ask about PrEP.

While you are taking PEP

  • Take every dose, at the same time each day, for the full 28 days.
  • Use condoms until your follow-up HIV tests confirm you are HIV-negative.
  • Go for follow-up HIV testing as the doctor advises.
  • Contact a doctor if you develop a rash, fever, yellow eyes or severe tummy pain.

Frequently asked questions

What is PEP?

PEP (post-exposure prophylaxis) is a 28-day course of antiretroviral medicine taken after a possible exposure to HIV, to reduce the chance of infection. It must be started within 72 hours of the exposure, and works best when started as soon as possible.

Can I get PEP online in South Africa?

A VDOC doctor can assess your exposure by video and, if PEP is clinically appropriate, issue a prescription. The doctor will also advise on HIV testing. If you cannot get an appointment quickly, don't wait. Go to a clinic or hospital emergency unit, where PEP is also available.

What if it has been more than 72 hours?

PEP is not recommended after 72 hours, because it is unlikely to work. Speak to a doctor about HIV testing at the right times and, if you are at ongoing risk, about starting PrEP.

Does PEP have side effects?

Some people get nausea, tiredness or headaches, which usually settle. It is important to take every dose for the full 28 days. The doctor will explain how to manage side effects.

Do I need an HIV test before starting PEP?

A baseline HIV test is part of PEP care, and follow-up tests are needed over the next few months. The doctor will explain where to test and when. Don't delay booking while you arrange a test.

I was sexually assaulted. Where should I go?

Please go to your nearest Thuthuzela Care Centre, hospital or police station as soon as possible. They can provide PEP, emergency contraception, STI treatment, forensic examination and counselling free of charge. You can also call the GBV Command Centre on 0800 428 428, 24 hours a day.

Other ways we can help

Ready to VDOC it?

PEP works best the sooner it starts. Book the earliest available doctor now, or go to a clinic or emergency unit.

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